The Safety and Efficacy of Growth Hormone Secretagogues Sigalos JT, Pastuszak AW · Baylor College of Medicine Sexual Medicine Reviews · 2017 · PMID: 28400207

The Study

A peer-reviewed clinical review examining growth hormone secretagogues (GHSs) — the compound class that includes sermorelin and tesamorelin. Researchers at Baylor College of Medicine analyzed the available human clinical literature on GHS safety and efficacy across multiple endpoints including body composition, sleep, bone density, and tolerability.

What They Found

• GHSs stimulate the body's own pulsatile GH release rather than replacing GH externally — meaning natural feedback loops stay intact

• Documented benefits across studies: increased lean mass, reduced fat mass, improved sleep quality, better bone turnover, appetite stimulation in wasting states

• Sleep findings are notable: ibutamoren produced a 50% increase in Stage 4 sleep and >20% increase in REM sleep in young men

• Sermorelin and tesamorelin are explicitly named as GHRH analogs in the same compound class, available via compounding pharmacies

Bottom Line

The clinical literature supports GH secretagogues as a well-tolerated alternative to exogenous GH, with documented effects on lean mass, sleep, and bone health. Long-term large-scale studies are still needed, and individual results vary.

Read the full article here: https://pmc.ncbi.nlm.nih.gov/articles/PMC5632578/